Prostamax

Prostamax is a synthetic peptide from the Khavinson family, primarily designed to repair and benefit the prostate[1]. This peptide has also demonstrated the capacity to enhance lymphocyte function and influence DNA expression patterns in various tissues. Prostamax stands out as one of the broader-spectrum anti-aging Khavinson peptides due to its ability to promote the decondensation of heterochromatin in a wide range of cells.

Research  suggests that Prostamax has the potential to treating chronic prostatitis. Although there is speculation that long-term usage could have cancer-preventive effects, studies of sufficient duration to establish this have yet to be conducted.

Chronic Prostate Inflammation

Chronic prostate inflammation (called chronic prostatitis) affects as many as 16% of men at some point in their lives. It is a painful condition causing burning with urination, urgency, and trouble voiding. It can even cause difficult or painful ejaculation along with pain in the lower back. It is notoriously difficult to treat, often requiring long-term antibiotic treatment over months. There is also good evidence to suggest that it can lead to cardiovascular disease and even cancer, so treating prostatitis is crucial to long-term health[2].

Research in rat models shows that prostatitis can be treated with Prostamax. which reduces the signs and symptoms of the disease. Rats treated with Prostamax for just 15 days showed reduce swelling of the prostate gland along with less vascular congestion (hyperemia) and less infiltration by cells of the immune system.

Interestingly, the rats also showed decreased levels of scarring in the prostate, indicating that the reduction in inflammation was slowing or even stopping pathological remodeling. Though the study was not carried out long enough or on enough rats to assess Prostamax’s effect on the risk for cancer, the results suggest that it would likely diminish the risk by reducing chronic inflammation that leads to pathological hypertrophy and hyperplasia[3].

According to Dr. Angelina Pakhomova, what makes the above study on Prostamax extra exciting is that it was effective in treating a form of prostatitis called chronic abacterial prostatitis (CAP). CAP is the most common form of prostatitis, but it is difficult to treat because it isn’t caused by a bacterial infection. Bacterial infections respond readily to antibiotics. CAP, on the other hand, does not respond as well to antibiotic treatment and sometimes doesn’t respond at all. It is also more likely to recur and has been shown to be exceptionally frustrating to those who suffer from it. Having an alternative treatment that is effective in CAP could improve qualitv of life for many men and ward off future disease Finding a treatment for CAP is more important than ever as rates of the condition have increased almost 3-fold since the end of the 20th century.

Prostamax and the Immune System

Though Prostamax is considered to be tissue-specific, there is ample evidence that the bioreulator acts on cells outside of the prostate. The most consequential effects are on the ribosomes and densely packed chromatin found in lymphocytes. In these cells, Prostamax, like Epithalon and Vilon, serves to increase expression of ribosomes which are responsible for the translation of mRNA into proteins. It also opens up densely packed chromatin to make genes more accessible for transcription into mRNA. Thus, Prostamax sets the stage for increased gene expression at every level, allowing for a functional change in the health of lymphocytes [4], [5].

The impact of Prostamax on the immune system is not just theoretical either. Research shows that the peptide helps to reduce signs of chronic prostate inflammation including swelling, hyperemia, and lymphocyte infiltration. [3] This results both from the influence Prostamax has on lymphocvtes and their control over the immune response as well as the role the peptide plays in normalizing growth and differentiation of prostate cells.

Prostamax and Aging

The effects that Prostamax has on lymphocytes and cells of the prostate are part of a larger effect it has one many different types of cells. Research in cell cultures taken from older individuals shows that Prostamax alters DNA structure by decondensing heterochromatin. This, in turn, allows for greater expression of DNA that was inactivated via dense packaging of DNA[6].

What makes this remarkable in terms of aging is that condensation of DNA is a normal, If undesirable, consequence of aging. DNA condensation is a primary driver of both senescence and apoptosis, making it one of the most important mechanisms of aging. By unpacking DNA, Prostamax is literally giving the cells a more youthful genetic profile. The results are increased proliferation of cells, decreased apoptosis (programmed cell death), and improved protein expression and cell function.

References

1. A. N. Zakutskit, N. I. Chalisova, G. A. Rvzhak, A. I. Aniskina, S. V. Filippov, and P N. Zeziulin. “The tissue-specific effect of svnthetic peptides-biologic reaulators organotypic tissues culture in young and old rats].” Adv. Gerontol. Uspekhi Gerontol., vol. 19, pp. 93-96, 2006.
2. “Treating chronic prostatitis.” Harvard Health, Dec. 21. https://www.health.harvard.edu/mens-health/treating-chronic-prostatitis
3. Borovskaya, T. , Pakhomova, A. , Vychuzhanina, A. , Poluektova, M. , Fomina, T. , Ermolaeva, L. , Schemerova, J. , Granstrem, O. and Neplochov, E. (2013) Experimental studying of the drug efficiency Prostamax in the therapy of chronic aseptic prostatitis and its complications. Modern Research in Inflammation, 2, 54-58. doi: 10.4236/mri.2013.23007.
4. Khavinson VKh, Lezhava TA, Malinin VV. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull Exp Biol Med. 2004 Jan;137(1):78-81. doi: 10.1023/b:bebm.0000024393.40560.05. PMID: 15085253.
5. Meskhi T, Khachidze D, Barbakadze Sh, Madzhagaladze G, Gorgoshidze M, Monaselidze D, Lezhava T, Tadumadze N. Vliianie peptidnogo bioreguliatora prostamaksa na geterokhromatin limfotsitov cheloveka in situ [The influence of the peptide bioregulator prostamax on heterochromatin of human lymphocytes in situ]. Biofizika. 2004 Nov-Dec;49(6):1091-3. Russian. PMID: 15612551.
6. Dzhokhadze TA, Buadze TZh, Gaĭozishvili MN, Baratashvili NA, Lezhava TA. [Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)]. Georgian Med News. 2012 Nov;(212):76-82. Russian. PMID: 23221144.
7. Khavinson VK, Kormilets DY, Mar’yanovich AT. Peptides (Epigenetic Regulators) in the Structure of Rodents with a Long and Short Lifespan. Bull Exp Biol Med. 2017 Sep;163(5):671-676. doi: 10.1007/s10517-017-3876-x. Epub 2017 Sep 25. PMID: 28948547.